' 
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 11 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Iron (as Dried Ferrous Sulfate)
45 mg
250%
Top Medical Research Studies
8
CUR-PDT triggers ferroptosis in RA
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
High relevance for RA treatment
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
Iron links to MS lesion recovery
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI.
High relevance for MS therapy
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9.5
Boosted mental health
I've been taking this vitamin for a couple of months and have experienced a significant enhancement in my overall health. I feel more alert and energised, which greatly benefits my creative thinking. It’s particularly useful for those with mental health conditions, including autoimmune disorders. I highly recommend it!
Read More
9.5
Noticeable improvements
I ordered iron for my mother, who has had lifelong anaemia, and domestic medications haven't helped much. After trying this affordable option, I was pleased that noticeable improvements came almost immediately. Muscle cramps disappeared by day two, and she now has no symptoms. This supplement truly works!
Read More
9.5
Raised hemoglobin levels
This iron supplement raised my hemoglobin level without causing significant discomfort, unlike others that triggered severe gastritis. I am pleased with my decision!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
CUR-PDT triggers ferroptosis in RA
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
High relevance for RA treatment
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
Iron links to MS lesion recovery
Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI.
High relevance for MS therapy
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Boosted mental health
I've been taking this vitamin for a couple of months and have experienced a significant enhancement in my overall health. I feel more alert and energised, which greatly benefits my creative thinking. It’s particularly useful for those with mental health conditions, including autoimmune disorders. I highly recommend it!
Read More
9.5
Noticeable improvements
I ordered iron for my mother, who has had lifelong anaemia, and domestic medications haven't helped much. After trying this affordable option, I was pleased that noticeable improvements came almost immediately. Muscle cramps disappeared by day two, and she now has no symptoms. This supplement truly works!
Read More
9.5
Raised hemoglobin levels
This iron supplement raised my hemoglobin level without causing significant discomfort, unlike others that triggered severe gastritis. I am pleased with my decision!
7
High-quality product
I finally discovered something remarkable. This is a high-quality product with excellent packaging. It offers great benefits and a nice impact. The price is reasonable, among the lowest on the market. I enjoyed free shipping as I ordered multiple items together, and it was delivered promptly. I highly recommend this product for those dealing with an autoimmune disorder.
Read More
8.8
Improved iron levels
Great! Last winter, I discovered my iron levels were deficient and purchased this brand. I am very satisfied with the results; they truly helped me. I ordered more.
